Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.

by Ana Terriente-Felix, Emma L Wilson, Alexander J Whitworth
Published 2020-10-01

Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

by Arash Shahsavari, Prasanna Weeratunga, Dmitry A. Ovchinnikov, Deanne J. Whitworth
Published 2021-02-01

Antioxidant Therapy in Parkinson’s Disease: Insights from <i>Drosophila melanogaster</i>

by Federica De Lazzari, Federica Sandrelli, Alexander J. Whitworth, Marco Bisaglia
Published 2020-01-01

A review of the accuracy of pre-operative radiological staging to identify locally advanced upper tract transitional cell carcinoma

by J. Jenkins, J. Whitworth, F. Abushamma, S. Kearley, F. Keeley, A. Mahrous, S. Albuheissi
Published 2020-07-01

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

by Federica De Lazzari, Hiran A. Prag, Anja V. Gruszczyk, Alexander J. Whitworth, Marco Bisaglia
Published 2021-05-01

Innovations and Advances in Schistosome Stem Cell Research

by Hong You, Malcolm K. Jones, Malcolm K. Jones, Deanne J. Whitworth, Donald P. McManus
Published 2021-03-01

Pyrosequencing Reveals the Predominance of Pseudomonadaceae in Gut Microbiome of a Gall Midge

by Raman Bansal, Scot H. Hulbert, John C. Reese, Robert J. Whitworth, Jeffrey J. Stuart, Ming-Shun Chen
Published 2014-06-01

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

by Joe H Pogson, Rachael M Ivatt, Alvaro Sanchez-Martinez, Roberta Tufi, Emma Wilson, Heather Mortiboys, Alexander J Whitworth
Published 2014-11-01

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.

by Alvaro Sanchez-Martinez, Manuel Calleja, Susana Peralta, Yuichi Matsushima, Rosana Hernandez-Sierra, Alexander J Whitworth, Laurie S Kaguni, Rafael Garesse
Published 2012-01-01

Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders.

by Domenica Lovero, Luca Giordano, René Massimiliano Marsano, Alvaro Sanchez-Martinez, Hadi Boukhatmi, Maik Drechsler, Marta Oliva, Alexander J Whitworth, Damiano Porcelli, Corrado Caggese
Published 2018-01-01

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

by Dmitry A. Ovchinnikov, Drew M. Titmarsh, Patrick R.J. Fortuna, Alejandro Hidalgo, Samah Alharbi, Deanne J. Whitworth, Justin J. Cooper-White, Ernst J. Wolvetang
Published 2014-09-01

Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

by Roberta Tufi, Thomas P. Gleeson, Sophia von Stockum, Victoria L. Hewitt, Juliette J. Lee, Ana Terriente-Felix, Alvaro Sanchez-Martinez, Elena Ziviani, Alexander J. Whitworth
Published 2019-04-01

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

by Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Published 2020-02-01

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

by Helen I. Woodroof, Joe H. Pogson, Mike Begley, Lewis C. Cantley, Maria Deak, David G. Campbell, Daan M. F. van Aalten, Alexander J. Whitworth, Dario R. Alessi, Miratul M. K. Muqit
Published 2011-01-01

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

by Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Published 2019-07-01

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

by Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Published 2021-08-01

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

by Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Published 2017-07-01

Investigations into the cellular function of C9orf72

by Webster, Christopher
Published 2016