Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

by Maarten Sijm, Louis Maes, Iwan J. P. de Esch, Guy Caljon, Geert Jan Sterk, Rob Leurs
Published 2021-04-01

Bromo-Cyclobutenaminones as New Covalent UDP-<i>N</i>-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

by David J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Miklós Keserű
Published 2020-11-01

In Silico Veritas: The Pitfalls and Challenges of Predicting GPCR-Ligand Interactions

by Sander B. Nabuurs, Jan P.G. Klomp, Rob Leurs, Jacob De Vlieg, Iwan J.P. De Esch, Bas Vroling, Marijn P.A. Sanders, Luc Roumen, Chris De Graaf
Published 2011-09-01

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

by Xavier Gómez-Santacana, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Rob Leurs
Published 2019-10-01

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations

by Inna Slynko, Stephanie Nguyen, Eline M. C. Hamilton, Lisanne E. Wisse, Iwan J. P. deEsch, Chris deGraaf, John B. Bruning, Christopher G. Proud, Truus E. M. Abbink, Marjo S. van derKnaap
Published 2021-03-01

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening

by Erik de Heuvel, Albert J. Kooistra, Ewald Edink, Sjors van Klaveren, Jeffrey Stuijt, Tiffany van der Meer, Payman Sadek, Dorien Mabille, Guy Caljon, Louis Maes, Marco Siderius, Iwan J. P. de Esch, Geert Jan Sterk, Rob Leurs
Published 2021-01-01

Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi

by Maarten Sijm, Julianna Siciliano de Araújo, Stefan Kunz, Susanne Schroeder, Ewald Edink, Kristina M. Orrling, An Matheeussen, Tiffany van de Meer, Payman Sadek, Hans Custers, Ignacio Cotillo, Julio J. Martin, Marco Siderius, Louis Maes, David G. Brown, Maria de Nazaré Correia Soeiro, GeertJan Sterk, Iwan J.P. de Esch, Rob Leurs
Published 2019-04-01

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

by Sanaa S. Botros, Samia William, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Sayed H. Seif el-Din, Alfonso García-Rubia, Victor Sebastián-Pérez, Antoni R. Blaazer, Erik de Heuvel, Maarten Sijm, Yang Zheng, Irene G. Salado, Jane C. Munday, Louis Maes, Iwan J.P. de Esch, Geert J. Sterk, Koen Augustyns, Rob Leurs, Carmen Gil, Harry P. De Koning
Published 2019-04-01