David Holcman

David Holcman is an applied mathematician, biophysicist and computational biologist at École Normale Supérieure in Paris. He is known for his work on the narrow escape problem, based on analysis of the Laplace equation, the redundancy principle in biology based on extreme statistics, the modeling of molecular trafficking in neurobiology, of diffusion and electrodiffusion in nanodomains such as dendritic spines, the modeling of neuronal networks dynamics such as Up and Down states in electrophysiology. He developed multiscale methods and simulations to analyse large amount of molecular super-resolution trajectories, and polymer physics modeling and analysis to study cell nucleus organization. These computational approaches led to several verified predictions in the life sciences such as nanocolumn organization of synapses or astrocytic protrusion penetrating neuronal synapses, molecular ER organization in dendritic spines and many more. The narrow escape theory was recently verified in physical experiments. Provided by Wikipedia