Product-Related Impurities in Clinical-Grade Recombinant AAV Vectors: Characterization and Risk Assessment

by J. Fraser Wright
Published 2014-03-01

Towards routine manufacturing of gene therapy drugs

by Otto-Wilhelm Merten, J Fraser Wright
Published 2016-01-01

Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes

by Bradley A. Hamilton, J. Fraser Wright
Published 2021-05-01

The intersection of vector biology, gene therapy, and hemophilia

by Leszek Lisowski, Janice M. Staber, J. Fraser Wright, Leonard A. Valentino
Published 2021-08-01

Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

by Benjamin J. Samelson-Jones, Jonathan D. Finn, Patricia Favaro, J. Fraser Wright, Valder R. Arruda
Published 2020-06-01

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

by Harrison C Brown, J Fraser Wright, Shangzhen Zhou, Allison M Lytle, Jordan E Shields, H Trent Spencer, Christopher B Doering
Published 2014-01-01

Proteomics analysis of co-purifying cellular proteins associated with rAAV vectors.

by Biao Dong, Xunbao Duan, Hoi Yee Chow, Lingxia Chen, Hui Lu, Wenman Wu, Bernd Hauck, Fraser Wright, Philipp Kapranov, Weidong Xiao
Published 2014-01-01

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis.

by Caroline J Aalbers, Lisette Bevaart, Scott Loiler, Karin de Cortie, J Fraser Wright, Federico Mingozzi, Paul P Tak, Margriet J Vervoordeldonk
Published 2015-01-01

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

by Allison M Lytle, Harrison C Brown, Na Yoon Paik, Kristopher A Knight, J Fraser Wright, H Trent Spencer, Christopher B Doering
Published 2016-01-01

Safety and tolerability of MRI-guided infusion of AAV2-hAADC into the mid-brain of nonhuman primate

by Waldy San Sebastian, Adrian P Kells, John Bringas, Lluis Samaranch, Piotr Hadaczek, Agnieszka Ciesielska, Michael J Macayan, Phillip J Pivirotto, John Forsayeth, Sheryl Osborne, J Fraser Wright, Foad Green, Gregory Heller, Krystof S Bankiewicz
Published 2014-01-01