Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators.

by Wei Wang, Jeong S Hong, Andras Rab, Eric J Sorscher, Kevin L Kirk
Published 2016-01-01

Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat.

by Michael S Stalvey, Viktoria Havasi, Katherine L Tuggle, Dezhi Wang, Susan Birket, Steve M Rowe, Eric J Sorscher
Published 2017-01-01

Correction: Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

by William T. Harris, David R. Kelly, Yong Zhou, Dezhi Wang, Mark MacEwen, James S. Hagood, J. P. Clancy, Namasivayam Ambalavanan, Eric J. Sorscher
Published 2013-01-01

Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease.

by William T Harris, David R Kelly, Yong Zhou, Dezhi Wang, Mark MacEwen, James S Hagood, J P Clancy, Namasivayam Ambalavanan, Eric J Sorscher
Published 2013-01-01

Correction: Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease.

by William T. Harris, David R. Kelly, Yong Zhou, Dezhi Wang, Mark MacEwen, James S. Hagood, J. P. Clancy, Namasivayam Ambalavanan, Eric J. Sorscher
Published 2013-01-01

Correction: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability

by Shaoyan Zhang, Angela C. Blount, Carmel M. McNicholas, Daniel F. Skinner, Michael Chestnut, John C. Kappes, Eric J. Sorscher, Bradford A. Woodworth
Published 2014-01-01

Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA.

by Aubrey E Hill, Zackery E Plyler, Hemant Tiwari, Amit Patki, Joel P Tully, Christopher W McAtee, Leah A Moseley, Eric J Sorscher
Published 2014-01-01

Correction: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability.

by Shaoyan Zhang, Angela C. Blount, Carmel M. McNicholas, Daniel F. Skinner, Michael Chestnut, John C. Kappes, Eric J. Sorscher, Bradford A. Woodworth
Published 2014-01-01

Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability.

by Shaoyan Zhang, Angela C Blount, Carmel M McNicholas, Daniel F Skinner, Michael Chestnut, John C Kappes, Eric J Sorscher, Bradford A Woodworth
Published 2013-01-01

Assessing cell-specific effects of genetic variations using tRNA microarrays

by Christine Polte, Daniel Wedemeyer, Kathryn E. Oliver, Johannes Wagner, Marcel J. C. Bijvelds, John Mahoney, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
Published 2019-07-01

Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.

by Shaoyan Zhang, Daniel Skinner, Stephen Bradley Hicks, Mark O Bevensee, Eric J Sorscher, Ahmed Lazrak, Sadis Matalon, Carmel M McNicholas, Bradford A Woodworth
Published 2014-01-01

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

by Guido Veit, Kathryn Oliver, Pirjo M Apaja, Doranda Perdomo, Aurélien Bidaud-Meynard, Sheng-Ting Lin, Jingyu Guo, Mert Icyuz, Eric J Sorscher, John L Hartman, Gergely L Lukacs
Published 2016-05-01

LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species

by Do Yeon Cho, Shaoyan Zhang, Ahmed Lazrak, Daniel Skinner, Harrison M. Thompson, Jessica Grayson, Purushotham Guroji, Saurabh Aggarwal, Zsuzsanna Bebok, Steven M. Rowe, Sadis Matalon, Eric J. Sorscher, Bradford A. Woodworth
Published 2021-07-01

A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease.

by Peter A Sloane, Suresh Shastry, Andrew Wilhelm, Clifford Courville, Li Ping Tang, Kyle Backer, Elina Levin, S Vamsee Raju, Yao Li, Marina Mazur, Suzanne Byan-Parker, William Grizzle, Eric J Sorscher, Mark T Dransfield, Steven M Rowe
Published 2012-01-01

Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography.

by Linbo Liu, Kengyeh K Chu, Grace H Houser, Bradford J Diephuis, Yao Li, Eric J Wilsterman, Suresh Shastry, Gregory Dierksen, Susan E Birket, Marina Mazur, Suzanne Byan-Parker, William E Grizzle, Eric J Sorscher, Steven M Rowe, Guillermo J Tearney
Published 2013-01-01

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule The...

by W Joon Chung, Jennifer L Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M Rowe, Zackery E Plyler, Jeong S Hong, Marina Mazur, Gary A Piazza, Adam B Keeton, E Lucile White, Lynn Rasmussen, Allan M Weissman, R Aldrin Denny, Jeffrey L Brodsky, Eric J Sorscher
Published 2016-01-01

Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats.

by Katherine L Tuggle, Susan E Birket, Xiaoxia Cui, Jeong Hong, Joe Warren, Lara Reid, Andre Chambers, Diana Ji, Kevin Gamber, Kengyeh K Chu, Guillermo Tearney, Li Ping Tang, James A Fortenberry, Ming Du, Joan M Cadillac, David M Bedwell, Steven M Rowe, Eric J Sorscher, Michelle V Fanucchi
Published 2014-01-01

Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells

by Ana M. Crane, Philipp Kramer, Jacquelin H. Bui, Wook Joon Chung, Xuan Shirley Li, Manuel L. Gonzalez-Garay, Finn Hawkins, Wei Liao, Daniela Mora, Sangbum Choi, Jianbin Wang, Helena C. Sun, David E. Paschon, Dmitry Y. Guschin, Philip D. Gregory, Darrell N. Kotton, Michael C. Holmes, Eric J. Sorscher, Brian R. Davis
Published 2015-04-01

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

by Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Published 2021-07-01