Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-prese...

by Mark A. J. M. Hendriks, Emily M. Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F. Samplonius, Wijnand Helfrich
Published 2020-01-01

A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint

by Iris Koopmans, Djoke Hendriks, Douwe F. Samplonius, Robert J. van Ginkel, Sandra Heskamp, Peter J. Wierstra, Edwin Bremer, Wijnand Helfrich
Published 2018-08-01

Galectin-9 activates and expands human T-helper 1 cells.

by Marloes J M Gooden, Valerie R Wiersma, Douwe F Samplonius, Jurjen Gerssen, Robert J van Ginkel, Hans W Nijman, Mitsuomi Hirashima, Toshiro Niki, Paul Eggleton, Wijnand Helfrich, Edwin Bremer
Published 2013-01-01

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab...

by Peter E. van Bommel, Yuan He, Ilona Schepel, Mark A. J. M. Hendriks, Valerie R. Wiersma, Robert J. van Ginkel, Tom van Meerten, Emanuele Ammatuna, Gerwin Huls, Douwe F. Samplonius, Wijnand Helfrich, Edwin Bremer
Published 2018-02-01