A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

by A. Marieke Oudelaar, Caroline L. Harrold, Lars L. P. Hanssen, Jelena M. Telenius, Douglas R. Higgs, Jim R. Hughes
Published 2019-11-01

ATRX dysfunction induces replication defects in primary mouse cells.

by David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Stephen Taylor, Matthew Mitson, Csanád Z Bachrati, Douglas R Higgs, Richard J Gibbons
Published 2014-01-01

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

by David Garrick, Jackie A Sharpe, Ruth Arkell, Lorraine Dobbie, Andrew J H Smith, William G Wood, Douglas R Higgs, Richard J Gibbons
Published 2006-04-01

Causes and consequences of chromatin variation between inbred mice.

by Mona Hosseini, Leo Goodstadt, Jim R Hughes, Monika S Kowalczyk, Marco de Gobbi, Georg W Otto, Richard R Copley, Richard Mott, Douglas R Higgs, Jonathan Flint
Published 2013-06-01

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

by Hsiao P.J. Voon, Jim R. Hughes, Christina Rode, Inti A. De La Rosa-Velázquez, Thomas Jenuwein, Robert Feil, Douglas R. Higgs, Richard J. Gibbons
Published 2015-04-01

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

by Yavor K. Bozhilov, Damien J. Downes, Jelena Telenius, A. Marieke Oudelaar, Emmanuel N. Olivier, Joanne C. Mountford, Jim R. Hughes, Richard J. Gibbons, Douglas R. Higgs
Published 2021-06-01

Considerations when investigating lncRNA function in vivo

by Andrew R Bassett, Asifa Akhtar, Denise P Barlow, Adrian P Bird, Neil Brockdorff, Denis Duboule, Anne Ephrussi, Anne C Ferguson-Smith, Thomas R Gingeras, Wilfried Haerty, Douglas R Higgs, Eric A Miska, Chris P Ponting
Published 2014-08-01

MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells

by Bryony Graham, Antoine Marcais, Gopuraja Dharmalingam, Thomas Carroll, Chryssa Kanellopoulou, Johannes Graumann, Tatyana B. Nesterova, Anna Bermange, Pijus Brazauskas, Barbara Xella, Skirmantas Kriaucionis, Douglas R. Higgs, Neil Brockdorff, Matthias Mann, Amanda G. Fisher, Matthias Merkenschlager
Published 2016-05-01

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

by Jill M. Brown, Nigel A. Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M. Telenius, Sara De Ornellas, A. Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs, Veronica J. Buckle
Published 2018-09-01

Dynamics of the 4D genome during in vivo lineage specification and differentiation

by A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes
Published 2020-06-01

A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells

by Andrea M. Chiariello, Simona Bianco, A. Marieke Oudelaar, Andrea Esposito, Carlo Annunziatella, Luca Fiorillo, Mattia Conte, Alfonso Corrado, Antonella Prisco, Martin S.C. Larke, Jelena M. Telenius, Renato Sciarretta, Francesco Musella, Veronica J. Buckle, Douglas R. Higgs, Jim R. Hughes, Mario Nicodemi
Published 2020-02-01

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

by Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons, Douglas R. Higgs
Published 2017-09-01

Reactivation of a developmentally silenced embryonic globin gene

by Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs
Published 2021-07-01