p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy

by Chunwan Lu, Kebin Liu, John D Klement, Alyssa D Smith, Dafeng Yang, Darren D Browning
Published 2020-07-01

Sildenafil normalizes bowel transit in preclinical models of constipation.

by Sarah K Sharman, Bianca N Islam, Yali Hou, Margaux Usry, Allison Bridges, Nagendra Singh, Subbaramiah Sridhar, Satish Rao, Darren D Browning
Published 2017-01-01

Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity.

by Huabin Zhu, Henrique Lemos, Brinda Bhatt, Bianca N Islam, Abhijit Singh, Ashish Gurav, Lei Huang, Darren D Browning, Andrew Mellor, Sadanand Fulzele, Nagendra Singh
Published 2017-01-01

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

by Mohammed L. Ibrahim, John D. Klement, Chunwan Lu, Priscilla S. Redd, Wei Xiao, Dafeng Yang, Darren D. Browning, Natasha M. Savage, Phillip J. Buckhaults, Herbert C. Morse, III, Kebin Liu
Published 2018-12-01