Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.

by Nathaniel J Schuldt, Yasser A Aldhamen, Daniel M Appledorn, Sergey S Seregin, Youssef Kousa, Sarah Godbehere, Andrea Amalfitano
Published 2011-01-01

TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.

by Sergey S Seregin, Yasser A Aldhamen, Daniel M Appledorn, Charles F Aylsworth, Sarah Godbehere, Chyong-Jy Joyce Liu, Dionisia Quiroga, Andrea Amalfitano
Published 2011-01-01

A new adenovirus based vaccine vector expressing an Eimeria tenella derived TLR agonist improves cellular immune responses to an antigenic target.

by Daniel M Appledorn, Yasser A Aldhamen, William Depas, Sergey S Seregin, Chyong-Jy J Liu, Nathan Schuldt, Darin Quach, Dionisia Quiroga, Sarah Godbehere, Igor Zlatkin, Sungjin Kim, J Justin McCormick, Andrea Amalfitano
Published 2010-03-01