Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents

by Hailey S. Butman, Timothy J. Kotzé, Cynthia S. Dowd, Erick Strauss
Published 2020-12-01

Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro

by René Chofor, Martijn D.P. Risseeuw, Jenny Pouyez, Chinchu Johny, Johan Wouters, Cynthia S. Dowd, Robin D. Couch, Serge Van Calenbergh
Published 2014-02-01

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy.

by Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek
Published 2012-01-01

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

by Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch
Published 2014-01-01

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

by Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Published 2017-08-01

Structure-guided microbial targeting of antistaphylococcal prodrugs

by Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Published 2021-07-01

Potent, specific MEPicides for treatment of zoonotic staphylococci.

by Rachel L Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T Shah, Justin J Miller, Andrew J Jezewski, Marwa O Mikati, Xu Wang, Robert C Brothers, Kenneth M Heidel, Damon M Osbourn, Carey-Ann D Burnham, Sophie Alvarez, Stephanie A Fritz, Cynthia S Dowd, Joseph M Jez, Audrey R Odom John
Published 2020-06-01