Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay

by Katharina Leitmeyer, Andrea Glutz, Cristian Setz, Leonie Wieland, Sulamith Egloff, Daniel Bodmer, Yves Brand
Published 2016-01-01

Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro

by Katharina Leitmeyer, Andrea Glutz, Vesna Radojevic, Cristian Setz, Nathan Huerzeler, Helen Bumann, Daniel Bodmer, Yves Brand
Published 2015-01-01

Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear.

by Yves Brand, Vesna Radojevic, Michael Sung, Eric Wei, Cristian Setz, Andrea Glutz, Katharina Leitmeyer, Daniel Bodmer
Published 2014-01-01

All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.

by Yves Brand, Soledad Levano, Vesna Radojevic, Arianne Monge Naldi, Cristian Setz, Allen F Ryan, Kwang Pak, Brian A Hemmings, Daniel Bodmer
Published 2015-01-01