A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.

by Nupura Hirve, Roman M Levytskyy, Stephanie Rigaud, David M Guimond, Tomasz Zal, Karsten Sauer, Constantine D Tsoukas
Published 2012-01-01

Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide.

by David M Guimond, Nicholas R Cam, Nupura Hirve, Wei Duan, John D Lambris, Michael Croft, Constantine D Tsoukas
Published 2013-01-01