Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

by Murphy, Charles J., Karreth, Florian A., Elemento, Olivier, Toker, Alex, Wulf, Gerburg M., Cantley, Lewis C., Yang, Kangkang, Liu, Hui, Emdal, Kristina Bennet, Cantley, Lewis C, White, Forest M.
Published 2019

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

by Hu, Jie, Locasale, Jason W., Bielas, Jason H., O'Sullivan, Jacintha, Sheahan, Kieran, Cantley, Lewis C., Vander Heiden, Matthew G., Vitkup, Dennis
Published 2014

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

by Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C, Jeanson, Nathaniel T, Clish, Clary B, Cantley, Lewis C, Scadden, David T, Israelsen, William James, Vander Heiden, Matthew G.
Published 2016

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

by Taniguchi, Cullen M., Winnay, Jonathon, Kondo, Tatsuya, Bronson, Roderick T., Guimaraes, Alexander R., Aleman, Jose O., Luo, Ji, Stephanopoulos, Gregory, Weissleder, Ralph, Cantley, Lewis C., Kahn, C. Ronald
Published 2013

Identification of CDCP1 as a hypoxia-inducible factor 2  (HIF-2 ) target gene that is associated with survival in clear cell renal cell carcinoma patients

by Emerling, B. M., Benes, Cyril H., Poulogiannis, G., Courtney, K., Liu, H., Choo-Wing, R., Bellinger, Gary, Tsukazawa, K. S., Brown, V., Signoretti, S., Soltoff, S. P., Cantley, Lewis C., Bell, Eric L.
Published 2013

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

by Vander Heiden, Matthew G., Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Gregory J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.
Published 2014

Metabolic Pathway Alterations that Support Cell Proliferation

by Vander Heiden, Matthew G., Lunt, Sophia Yunkyungkwon, Dayton, Talya Lucia, Fiske, Brian Prescott, Israelsen, William James, Mattaini, Katherine Ruth, Vokes, N. I., Stephanopoulos, G., Cantley, Lewis C., Metallo, Christian M., Locasale, Jason W.
Published 2013

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

by Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B., Israelsen, William James
Published 2015

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

by Vander Heiden, Matthew G., Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Gary, Bellinger, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Cantley, Lewis C., Bellinger, Gary
Published 2013

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

by Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y, Chapski, Douglas J, Jeong, Seung Min, Dempsey, Jamie M., Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth P., Haigis, Marcia C., Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John
Published 2014

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

by Banko, Max R, Allen, Jasmina J, Schaffer, Bethany E, Wilker, Erik W, Tsou, Peiling, White, Jamie L, Villen, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B, Shokat, Kevan M, Brunet, Anne
Published 2015

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

by Garcia-Cao, Isabel, Song, Min Sup, Hobbs, Robin M, Laurent, Gaelle, Giorgi, Carlotta, de Boer, Vincent C. J., Anastasiou, Dimitrios, Ito, Keisuke, Sasaki, Atsuo T, Rameh, Lucia, Carracedo, Arkaitz, Vander Heiden, Matthew G, Cantley, Lewis C., Pinton, Paolo, Haigis, Marcia C., Pandolfi, Pier Paolo, Vander Heiden, Matthew G.
Published 2014

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

by Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Published 2014

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

by Yi, Caroline H, Pan, Heling, Seebacher, Jan, Jang, Il-Ho, Hyberts, Sven G, Heffron, Gregory J., Vander Heiden, Matthew G, Yang, Renliang, Li, Fupeng, Locasale, Jason W., Sharfi, Hadar, Zhai, Bo, Rodriguez-Mias, Ricard, Luithardt, Harry, Cantley, Lewis C., Daley, George Q., Asara, John M., Gygi, Steven P., Wagner, Gerhard, Liu, Chuan-Fa, Yuan, Junying
Published 2014

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

by Li, Jie, Sasaki, Mika, Horner, James W, Burga, Laura N, Xie, Jianxin, Jurczak, Michael J, DePinho, Ronald A, Clish, Clary B, Kibbey, Richard G, Wulf, Gerburg M, Di Vizio, Dolores, Mills, Gordon B, Cantley, Lewis C, Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2017

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

by Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine Ruth, Bass, Adam J., Heffron, Gregory J., Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew L., Richardson, Andrea L., Chin, Lynda, Wagner, Gerhard, Asara, John M., Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.
Published 2013