The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

by Andrea Cerquone Perpetuini, Justine Mathoux, Breandán N Kennedy
Published 2019-01-01

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

by Nils Ohnesorge, Temitope Sasore, Daniel Hillary, Yolanda Alvarez, Michelle Carey, Breandán N. Kennedy
Published 2019-05-01

Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration

by Stephen P. Carter, Stephen P. Carter, Ailís L. Moran, Ailís L. Moran, David Matallanas, Gavin J. McManus, Oliver E. Blacque, Oliver E. Blacque, Breandán N. Kennedy, Breandán N. Kennedy
Published 2020-03-01

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

by Rebecca Ward, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Published 2018-04-01

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

by Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Ailis Moran, Eugene T. Dillion, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy, Breandán N. Kennedy
Published 2020-08-01

Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

by Lorraine Burke, Lorraine Burke, Clare T. Butler, Adrian Murphy, Bruce Moran, William M Gallagher, Jacintha O'Sullivan, Breandán N. Kennedy
Published 2016-09-01

Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells

by Amy M. Buckley, Becky AS. Bibby, Margaret R. Dunne, Susan A. Kennedy, Maria B. Davern, Breandán N. Kennedy, Stephen G. Maher, Jacintha O’Sullivan
Published 2019-02-01

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4

by Ismael Obaidi, Hilary Cassidy, Verónica Ibáñez Gaspar, Jasmin McCaul, Michael Higgins, Melinda Halász, Alison L. Reynolds, Breandan N. Kennedy, Tara McMorrow
Published 2020-05-01

Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

by Yolanda Alvarez, Olaya Astudillo, Lasse Jensen, Alison L Reynolds, Nora Waghorne, Derek P Brazil, Yihai Cao, John J O'Connor, Breandán N Kennedy
Published 2009-11-01

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

by Jyothi S Akella, Stephen P Carter, Ken Nguyen, Sofia Tsiropoulou, Ailis L Moran, Malan Silva, Fatima Rizvi, Breandan N Kennedy, David H Hall, Maureen M Barr, Oliver E Blacque
Published 2020-02-01

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysisResearch in context

by Sarah M. Wade, Nils Ohnesorge, Hayley McLoughlin, Monika Biniecka, Steven P. Carter, Michelle Trenkman, Clare C. Cunningham, Trudy McGarry, Mary Canavan, Breandán N. Kennedy, Douglas J. Veale, Ursula Fearon
Published 2019-09-01

Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.

by Victor L Jensen, Stephen Carter, Anna A W M Sanders, Chunmei Li, Julie Kennedy, Tiffany A Timbers, Jerry Cai, Noemie Scheidel, Breandán N Kennedy, Ryan D Morin, Michel R Leroux, Oliver E Blacque
Published 2016-12-01

Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

by Susan A. Kennedy, Maria E. Morrissey, Margaret R. Dunne, Fiona O’Connell, Clare T. Butler, Mary-Clare Cathcart, Amy M. Buckley, Brian J. Mehigan, John O. Larkin, Paul McCormick, Breandán N. Kennedy, Jacintha O’Sullivan
Published 2020-10-01

Inhibition of the Pim1 oncogene results in diminished visual function.

by Jun Yin, Lisa Shine, Francis Raycroft, Sudhakar Deeti, Alison Reynolds, Kristin M Ackerman, Antonino Glaviano, Sean O'Farrell, Olivia O'Leary, Claire Kilty, Ciaran Kennedy, Sarah McLoughlin, Megan Rice, Eileen Russell, Desmond G Higgins, David R Hyde, Breandan N Kennedy
Published 2012-01-01

Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

by Amy M. Buckley, Margaret R. Dunne, Maria E. Morrissey, Susan A. Kennedy, Aoife Nolan, Maria Davern, Emma K. Foley, Niamh Clarke, Joanne Lysaght, Narayanasamy Ravi, Dermot O’Toole, Finbar MacCarthy, John V. Reynolds, Breandán N. Kennedy, Jacintha O’Sullivan
Published 2020-07-01

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Me...

by Kayleigh Slater, Aisling B. Heeran, Sandra Garcia-Mulero, Helen Kalirai, Rebeca Sanz-Pamplona, Arman Rahman, Nebras Al-Attar, Mays Helmi, Fiona O’Connell, Rosa Bosch, Anna Portela, Alberto Villanueva, William M. Gallagher, Lasse D. Jensen, Josep M. Piulats, Sarah E. Coupland, Jacintha O’Sullivan, Breandán N. Kennedy
Published 2020-10-01