Resisting the Heat: Bacterial Disaggregases Rescue Cells From Devastating Protein Aggregation

by Panagiotis Katikaridis, Valentin Bohl, Axel Mogk
Published 2021-05-01

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

by Célia Deville, Kamila Franke, Axel Mogk, Bernd Bukau, Helen R. Saibil
Published 2019-06-01

Structure of the VipA/B Type VI Secretion Complex Suggests a Contraction-State-Specific Recycling Mechanism

by Sebastian Kube, Nicole Kapitein, Tomasz Zimniak, Franz Herzog, Axel Mogk, Petra Wendler
Published 2014-07-01

Monitoring protein misfolding by site-specific labeling of proteins in vivo.

by Tzung-yang Hsieh, Nadinath B Nillegoda, Jens Tyedmers, Bernd Bukau, Axel Mogk, Günter Kramer
Published 2014-01-01

Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

by Fabian den Brave, Lucas V. Cairo, Chandhuru Jagadeesan, Carmen Ruger-Herreros, Axel Mogk, Bernd Bukau, Stefan Jentsch
Published 2020-06-01

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

by Chi-ting Ho, Tomas Grousl, Oren Shatz, Areeb Jawed, Carmen Ruger-Herreros, Marije Semmelink, Regina Zahn, Karsten Richter, Bernd Bukau, Axel Mogk
Published 2019-10-01

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

by Sophia Ungelenk, Fatemeh Moayed, Chi-Ting Ho, Tomas Grousl, Annette Scharf, Alireza Mashaghi, Sander Tans, Matthias P. Mayer, Axel Mogk, Bernd Bukau
Published 2016-11-01

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

by Marta Carroni, Eva Kummer, Yuki Oguchi, Petra Wendler, Daniel K Clare, Irmgard Sinning, Jürgen Kopp, Axel Mogk, Bernd Bukau, Helen R Saibil
Published 2014-04-01

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

by Marta Carroni, Kamila B Franke, Michael Maurer, Jasmin Jäger, Ingo Hantke, Felix Gloge, Daniela Linder, Sebastian Gremer, Kürşad Turgay, Bernd Bukau, Axel Mogk
Published 2017-11-01

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

by Ryo Yonashiro, Erich B Tahara, Mario H Bengtson, Maria Khokhrina, Holger Lorenz, Kai-Chun Chen, Yu Kigoshi-Tansho, Jeffrey N Savas, John R Yates III, Steve A Kay, Elizabeth A Craig, Axel Mogk, Bernd Bukau, Claudio AP Joazeiro
Published 2016-03-01