Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

by Kurt R. Brunden, Virginia M-Y. Lee, Amos B. Smith, III, John Q. Trojanowski, Carlo Ballatore
Published 2017-09-01

Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

by Claudia A. Jette, Christopher O. Barnes, Sharon M. Kirk, Bruno Melillo, Amos B. Smith, Pamela J. Bjorkman
Published 2021-03-01

An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.

by Alon Herschhorn, Andres Finzi, David M Jones, Joel R Courter, Akihiro Sugawara, Amos B Smith, Joseph G Sodroski
Published 2011-01-01

Elicitation of Cluster A and Co-Receptor Binding Site Antibodies are Required to Eliminate HIV-1 Infected Cells

by Guillaume Beaudoin-Bussières, Jérémie Prévost, Gabrielle Gendron-Lepage, Bruno Melillo, Junhua Chen, Amos B. Smith III, Marzena Pazgier, Andrés Finzi
Published 2020-05-01

Identification of novel inhibitors of dietary lipid absorption using zebrafish.

by Justin D Clifton, Edinson Lucumi, Michael C Myers, Andrew Napper, Kotaro Hama, Steven A Farber, Amos B Smith, Donna M Huryn, Scott L Diamond, Michael Pack
Published 2010-08-01

Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

by Hillel Haim, Bettina Strack, Aemro Kassa, Navid Madani, Liping Wang, Joel R Courter, Amy Princiotto, Kathleen McGee, Beatriz Pacheco, Michael S Seaman, Amos B Smith, Joseph Sodroski
Published 2011-06-01

Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site.

by Young Do Kwon, Judith M LaLonde, Yongping Yang, Mark A Elban, Akihiro Sugawara, Joel R Courter, David M Jones, Amos B Smith, Asim K Debnath, Peter D Kwong
Published 2014-01-01

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

by Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden
Published 2018-11-01

Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.

by Hillel Haim, Zhihai Si, Navid Madani, Liping Wang, Joel R Courter, Amy Princiotto, Aemro Kassa, Marciella DeGrace, Kathleen McGee-Estrada, Megan Mefford, Dana Gabuzda, Amos B Smith, Joseph Sodroski
Published 2009-04-01

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

by Alon Herschhorn, Xiaochu Ma, Christopher Gu, John D. Ventura, Luis Castillo-Menendez, Bruno Melillo, Daniel S. Terry, Amos B. Smith, Scott C. Blanchard, James B. Munro, Walther Mothes, Andrés Finzi, Joseph Sodroski
Published 2016-10-01

The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

by Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski
Published 2017-10-01

Publisher Correction: The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

by Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski
Published 2018-01-01

Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

by Jonathan Richard, Maxime Veillette, Shilei Ding, Daria Zoubchenok, Nirmin Alsahafi, Mathieu Coutu, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Amos B. Smith III, George M. Shaw, Beatrice H. Hahn, Joseph Sodroski, Daniel E. Kaufmann, Andrés Finzi
Published 2016-01-01

A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

by Navid Madani, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A. Zhao, Brandon P. Conn, Todd Bradley, M. Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F. Haynes, Amos B. Smith III, Sampa Santra, Joseph Sodroski
Published 2018-06-01

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins

by Jonathan Richard, Beatriz Pacheco, Neelakshi Gohain, Maxime Veillette, Shilei Ding, Nirmin Alsahafi, William D. Tolbert, Jérémie Prévost, Jean-Philippe Chapleau, Mathieu Coutu, Manxue Jia, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Loïc Martin, Cécile Tremblay, Beatrice H. Hahn, Daniel E. Kaufmann, Xueling Wu, Amos B. Smith III, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Published 2016-10-01

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

by Jérémie Prévost, William D. Tolbert, Halima Medjahed, Rebekah T. Sherburn, Navid Madani, Daria Zoubchenok, Gabrielle Gendron-Lepage, Althea E. Gaffney, Melissa C. Grenier, Sharon Kirk, Natasha Vergara, Changze Han, Brendan T. Mann, Agnès L. Chénine, Adel Ahmed, Irwin Chaiken, Frank Kirchhoff, Beatrice H. Hahn, Hillel Haim, Cameron F. Abrams, Amos B. Smith, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Published 2020-05-01

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity

by Todd Bradley, Ashley Trama, Nancy Tumba, Elin Gray, Xiaozhi Lu, Navid Madani, Fatemeh Jahanbakhsh, Amanda Eaton, Shi-Mao Xia, Robert Parks, Krissey E. Lloyd, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Susan Barnett, Salim S. Abdool-Karim, Scott D. Boyd, Bruno Melillo, Amos B. Smith III, Joseph Sodroski, Thomas B. Kepler, S.Munir Alam, Feng Gao, Mattia Bonsignori, Hua-Xin Liao, M. Anthony Moody, David Montefiori, Sampa Santra, Lynn Morris, Barton F. Haynes
Published 2016-10-01