Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer’s Disease

by Juan R. Perea, Juan R. Perea, Alberto Lleó, Alberto Lleó, Daniel Alcolea, Daniel Alcolea, Juan Fortea, Juan Fortea, Jesús Ávila, Jesús Ávila, Marta Bolós, Marta Bolós
Published 2018-09-01

Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer’s disease

by Neus Barranco, Virginia Plá, Daniel Alcolea, Irene Sánchez-Domínguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleó, Fernando Aguado
Published 2021-09-01

The proton-pump inhibitor lansoprazole enhances amyloid beta production.

by Nahuai Badiola, Victor Alcalde, Albert Pujol, Lisa-Marie Münter, Gerd Multhaup, Alberto Lleó, Mireia Coma, Montserrat Soler-López, Patrick Aloy
Published 2013-01-01

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

by Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Carla San Martín-Paniello, Jordi Clarimon, Olivia Belbin, Juan Fortea, Alberto Lleó
Published 2017-06-01

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.

by Nahuai Badiola, Rita Machado de Oliveira, Federico Herrera, Cristina Guardia-Laguarta, Susana A Gonçalves, Marta Pera, Marc Suárez-Calvet, Jordi Clarimon, Tiago Fleming Outeiro, Alberto Lleó
Published 2011-01-01

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease

by Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez, Alfredo J. Miñano-Molina
Published 2019-05-01

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease

by María-Salud García-Ayllón, Inmaculada Lopez-Font, Claudia P. Boix, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero
Published 2017-05-01

A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease.

by Olga Calero, María J Bullido, Jordi Clarimón, Ana Frank-García, Pablo Martínez-Martín, Alberto Lleó, María Jesús Rey, Isabel Sastre, Alberto Rábano, Jesús de Pedro-Cuesta, Isidro Ferrer, Miguel Calero
Published 2012-01-01

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

by Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, LonDownS Consortium, André Strydom
Published 2019-03-01

Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases

by Laia Lidón, Laura Urrea, Franc Llorens, Vanessa Gil, Ignacio Alvarez, Monica Diez-Fairen, Miguel Aguilar, Pau Pastor, Inga Zerr, Daniel Alcolea, Alberto Lleó, Enric Vidal, Rosalina Gavín, Isidre Ferrer, Jose Antonio Del Rio
Published 2020-05-01

Challenges associated with biomarker‐based classification systems for Alzheimer's disease

by Ignacio Illán‐Gala, Jordi Pegueroles, Victor Montal, Eduard Vilaplana, María Carmona‐Iragui, Daniel Alcolea, Bradford C. Dickerson, Raquel Sánchez‐Valle, Mony J. deLeon, Rafael Blesa, Alberto Lleó, Juan Fortea, Alzheimer's Disease Neuroimaging Initiative
Published 2018-01-01

White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation

by Charlotte E. Teunissen, Markus Otto, Sebastiaan Engelborghs, Sanna-Kaisa Herukka, Sylvain Lehmann, Piotr Lewczuk, Alberto Lleó, Armand Perret-Liaudet, Hayrettin Tumani, Martin R. Turner, Marcel M. Verbeek, Jens Wiltfang, Henrik Zetterberg, Lucilla Parnetti, Kaj Blennow
Published 2018-03-01

Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.

by Olga Calero, María J Bullido, Jordi Clarimón, Ana Frank-García, Pablo Martínez-Martín, Alberto Lleó, María Jesús Rey, Alberto Rábano, Rafael Blesa, Teresa Gómez-Isla, Fernando Valdivieso, Jesús de Pedro-Cuesta, Isidro Ferrer, Miguel Calero
Published 2011-01-01

Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse

by Daniel Alcolea, Jordi Pegueroles, Laia Muñoz, Valle Camacho, Diego López‐Mora, Alejandro Fernández‐León, Nathalie Le Bastard, Els Huyck, Alicia Nadal, Verónica Olmedo, Frederic Sampedro, Victor Montal, Eduard Vilaplana, Jordi Clarimón, Rafael Blesa, Juan Fortea, Alberto Lleó
Published 2019-09-01

Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests

by Bessy Benejam, Laura Videla, Eduard Vilaplana, Isabel Barroeta, Maria Carmona‐Iragui, Miren Altuna, Silvia Valldeneu, Susana Fernandez, Sandra Giménez, Florencia Iulita, Diana Garzón, Alexandre Bejanin, David Bartrés‐Faz, Sebastià Videla, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Juan Fortea
Published 2020-01-01

Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia

by Carmen Lage, Carmen Lage, Sara López-García, Alexandre Bejanin, Alexandre Bejanin, Martha Kazimierczak, Martha Kazimierczak, Ignacio Aracil-Bolaños, Alberto Calvo-Córdoba, Ana Pozueta, Ana Pozueta, María García-Martínez, María García-Martínez, Andrea Fernández-Rodríguez, María Bravo-González, Julio Jiménez-Bonilla, Ignacio Banzo, Juan Irure-Ventura, Jordi Pegueroles, Jordi Pegueroles, Ignacio Illán-Gala, Ignacio Illán-Gala, Juan Fortea, Juan Fortea, Eloy Rodríguez-Rodríguez, Eloy Rodríguez-Rodríguez, Alberto Lleó-Bisa, Alberto Lleó-Bisa, Cecilia E. García-Cena, Pascual Sánchez-Juan, Pascual Sánchez-Juan
Published 2021-02-01

Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

by Anna M. De Kort, H. Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A. M. Versleijen, Steven M. Greenberg, Erik Stoops, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Alberto Lleó, Jurgen A. H. R. Claassen, Marcel M. Verbeek
Published 2021-09-01

Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis

by Inmaculada Lopez-Font, Aitana Sogorb-Esteve, Míriam Javier-Torrent, Gunnar Brinkmalm, Mireia Herrando-Grabulosa, Belen García-Lareu, Janina Turon-Sans, Ricardo Rojas-García, Alberto Lleó, Carlos A. Saura, Henrik Zetterberg, Kaj Blennow, Assumpció Bosch, Xavier Navarro, Javier Sáez-Valero
Published 2019-04-01

Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early‐onset Alzheimer's disease

by Alain D. Dekker, Yannick Vermeiren, Maria Carmona‐Iragui, Bessy Benejam, Laura Videla, Ellen Gelpi, Tony Aerts, Debby Van Dam, Susana Fernández, Alberto Lleó, Sebastian Videla, Anne Sieben, Jean‐Jacques Martin, Netherlands Brain Bank, Rafael Blesa, Juan Fortea, Peter P. De Deyn
Published 2018-01-01

Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

by Olivia Belbin, Mei-Fang Xiao, Desheng Xu, Maria Carmona-Iragui, Jordi Pegueroles, Bessy Benejam, Laura Videla, Susana Fernández, Isabel Barroeta, Raúl Nuñez-Llaves, Victor Montal, Eduard Vilaplana, Miren Altuna, Jordi Clarimón, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Paul F. Worley, Juan Fortea
Published 2020-08-01