In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Promising Cyclooxygenase Inhibitors

by Krzysztof Peregrym, Łukasz Szczukowski, Benita Wiatrak, Katarzyna Potyrak, Żaneta Czyżnikowska, Piotr Świątek
Published 2021-08-01

Effect of pyrrolo[3,4-d]pyridazinone derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells

by Katarzyna Potyrak, Benita Wiatrak, Edward Krzyżak, Łukasz Szczukowski, Piotr Świątek, Adam Szeląg
Published 2021-09-01

Effect of Novel Pyrrolo[3,4-<i>d</i>]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation

by Karolina Wakulik, Benita Wiatrak, Łukasz Szczukowski, Dorota Bodetko, Marta Szandruk-Bender, Agnieszka Dobosz, Piotr Świątek, Kazimierz Gąsiorowski
Published 2020-04-01

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-<i>d</i>]Pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors

by Łukasz Szczukowski, Edward Krzyżak, Adrianna Zborowska, Patrycja Zając, Katarzyna Potyrak, Krzysztof Peregrym, Benita Wiatrak, Aleksandra Marciniak, Piotr Świątek
Published 2020-12-01

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxic...

by Marta Szandruk-Bender, Benita Wiatrak, Łukasz Szczukowski, Piotr Świątek, Maria Rutkowska, Stanisław Dzimira, Anna Merwid-Ląd, Maciej Danielewski, Adam Szeląg
Published 2020-12-01