Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and...

by Joanna Floros, Joanna Floros, Nithyananda Thorenoor, Nithyananda Thorenoor, Nikolaos Tsotakos, David S. Phelps
Published 2021-08-01

Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae

by Nithyananda Thorenoor, Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi, Joanna Floros, Joanna Floros
Published 2020-06-01

Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure

by Nithyananda Thorenoor, David S. Phelps, Joanna Floros
Published 2020-11-01

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant...

by Nithyananda Thorenoor, Todd M. Umstead, Xuesheng Zhang, David S. Phelps, Joanna Floros, Joanna Floros
Published 2018-10-01

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

by Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros
Published 2018-02-01

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences

by Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi, Xuesheng Zhang, Joanna Floros, Joanna Floros
Published 2019-08-01

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

by George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Published 2017-12-01

Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome

by George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros, Joanna Floros
Published 2019-07-01

Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to <i>Klebsiella pneumoniae</i> Infection and Ozone: Serendipity in Action

by Nithyananda Thorenoor, David S. Phelps, Padma Kala, Radhika Ravi, Andreas Floros Phelps, Todd M. Umstead, Xuesheng Zhang, Joanna Floros
Published 2020-08-01

Association of SNP–SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure

by Chintan K. Gandhi, Chixiang Chen, Rongling Wu, Lili Yang, Nithyananda Thorenoor, Neal J. Thomas, Susan L. DiAngelo, Debbie Spear, Garrett Keim, Nadir Yehya, Joanna Floros
Published 2020-04-01

Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis

by Zhenwu Lin, Nithyananda Thorenoor, Rongling Wu, Susan L. DiAngelo, Meixia Ye, Meixia Ye, Neal J. Thomas, Xiaojie Liao, Tony R. Lin, Stuart Warren, Joanna Floros, Joanna Floros
Published 2018-10-01