Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.

by Ruth Ann Veach, Jozef Zienkiewicz, Robert D Collins, Jacek Hawiger
Published 2012-01-01

Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles

by Yan Liu, Jozef Zienkiewicz, Kelli L. Boyd, Taylor E. Smith, Zhi-Qi Xu, Jacek Hawiger
Published 2021-06-01

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.

by Ruth Ann Veach, Yan Liu, Jozef Zienkiewicz, Lukasz S Wylezinski, Kelli L Boyd, James L Wynn, Jacek Hawiger
Published 2017-01-01

The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

by Antonio DiGiandomenico, Ruth Ann Veach, Jozef Zienkiewicz, Daniel J Moore, Lukasz S Wylezinski, Martha A Hutchens, Jacek Hawiger
Published 2014-01-01

In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes.

by Daniel J Moore, Jozef Zienkiewicz, Peggy L Kendall, Danya Liu, Xueyan Liu, Ruth Ann Veach, Robert D Collins, Jacek Hawiger
Published 2010-10-01